Evaluation of Serum Copper Level in Pregnant Women with High Hemoglobin

Adverse outcomes of pregnancy increase among women with high density of hemoglobin. This study evaluates the effects of iron supplementation on serum copper level in pregnant women with hemoglobin higher than 13.2 g/dl. Sixty two pregnant women with Hemoglobin >13.2 g/dl and normal serum copper levels in their 13-18 weeks of gestation were randomized into case and control groups. From 20th week till the end of the pregnancy ferrous sulfate tablets (150 mg tablet, containing 50 mg elemental iron) were given to the case group whereas, the controls received daily placebo tablets. Hemoglobin and serum copper levels were measured during the weeks of 24 to 28 (first trimester) and 32 to 36 (second trimester). Serum copper level of the case group during the second and third trimester was significantly lower than of the control group. It is concluded that, iron supplementation in pregnant women with hemoglobin above 13.2 g/dl possibility increases the risk of copper deficiency.Iran J Med Sci 2006; 31(3): 170-172. Keywords ● Pregnancy ● hemoglobin ● copper